Since chxt, he is at UCSF. His early PhD and postdoctoral work in the laboratory of Dr. Fernando Nottebohm demonstrated the migration of young neurons in adult song birds; showed that long projection neurons continue to form in the high vocal center of adult songbirds, and that radial glial cells in adult birds not only serve as guides for neuronal migration, but are also the precursors of the new neurons.
He and colleagues then identifies in the adult mammalian brain subventricular zone SVZ a large population of neuronal precursors; demonstrates long range migration of young neurons from the SVZ to the olfactory bulb; Identified the mechanism of cell translocation as chain migration and uncovered an extensive network of pathways for chain migration in the adult mammalian brain. In a surprising observation, his group has recently shown that the polarization of ependymal cells helps guide neuronal migration in the adult brain.
The Alvarez-Buylla laboratory identified the neural stem cells in the adult mammalian brain SVZ and hippocampus.
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